Modular construction of mammalian gene circuits using TALE transcriptional repressors
نویسندگان
چکیده
منابع مشابه
Modular construction of mammalian gene circuits using TALE transcriptional repressors
An important goal of synthetic biology is the rational design and predictable implementation of synthetic gene circuits using standardized and interchangeable parts. However, engineering of complex circuits in mammalian cells is currently limited by the availability of well-characterized and orthogonal transcriptional repressors. Here, we introduce a library of 26 reversible transcription activ...
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ژورنال
عنوان ژورنال: Nature Chemical Biology
سال: 2015
ISSN: 1552-4450,1552-4469
DOI: 10.1038/nchembio.1736